Hello and welcome to the forum.
There may be someone who sees your post, with a similar configuration, who might have an answer for you, but.....
That sounds to me like a question better put to Quick Books, as they would be more likely to have performed some testing with respect to their Point Of Sale product and determined it's compatibility or lack there of with Windows 10.
Good luck and if you find a definitive answer.....
Keep us posted
Regards
Randy