My 2 cents. proxomitron is an outdated program and has compatibility problems with Windows 10. I would suggest you uninstall it, at least temporarily, and see if there are any improvements.
Also, explore.exe is not a windows component. It is listed as a logging virus. I would suggest, before you totally remove it from the startup panel, that you first right click it and go to the file location. Change its name from "exe" to "dub" or something equally ridiculous.. Restart your computer and see if you are rid of it in the startup panel.